mPFS: 5.6 months with FOTIVDA vs 3.9 months with sorafenib (HR=0.73 [95% CI: 0.56, 0.95], P=0.02)1
mPFS: 5.6 months with FOTIVDA vs 3.9 months with sorafenib (HR=0.73 [95% CI: 0.56, 0.95], P=0.02)1
Tivozanib (FOTIVDA) is an NCCN recommended option for relapsed or stage IV ccRCC following ≥2 prior systemic therapies, including IO2
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References: 1. Rini BI, Pak SK, Escudier BJ, et al. Tivozanib versus sorafenib in patients with advanced renal cell carcinoma (TIVO-3): a phase 3, multicentre, randomised, controlled, open-label study. Lancet Oncol. 2020;21(1):95-104. 2. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Kidney Cancer V.2.2025. © National Comprehensive Cancer Network, Inc. 2024. All rights reserved. Accessed September 11, 2024. To view the most recent and complete version of the guideline, go online to NCCN.org.
See Pedro Barata, MD, MSc, and Director of GU Medical Oncology Research Program, University Hospitals Seidman Cancer Center, discuss a GU oncologist’s perspective on managing patients eligible for 3L treatment with FOTIVDA.
ccRCC=clear cell renal carcinoma; CI=confidence interval; HR=hazard ratio; IO=immuno-oncology; mPFS=median progression-free survival; NCCN=National Comprehensive Cancer Network® (NCCN®); rrRCC=relapsed/refractory renal cell carcinoma; TKI=tyrosine kinase inhibitor; VEGFR=vascular endothelial growth factor receptor.